molecular hydrogen nrf2 glutathione activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer: Cell Metabolism Nrf2 as a regulator of

The existing body of literature underscores the challenges associated with GSH's poor bioavailability, attributed to its unfavorable biochemical and pharmacokinetic properties 10,16

These include genes encoding catalase, peroxiredoxin, thioredoxin and thioredoxin reductase, a glutaredoxin-related protein, rubredoxin and rubrerythrin, a homolog for the peroxide stress protein YaaA 69 , and an arginase, which, through its catabolism of L-arginine, is hypothesized to limit this amino acid for the host synthesis of nitric oxide, a compound involved in host defense and host immune responses 35

173,174 In addition, arginine methylation also affects proteinprotein interactions involved in various cellular processes such as protein trafficking, signal transduction and transcriptional regulation

For anti-aging and longevity optimization, the priority shifts from acute metabolic correction to long-term mitochondrial maintenance and senescence suppression