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In the plasma, IGFBP-3 is bound to a protein called acid labile subunit (ALS), which stabilizes the IGFBP3-IGF-I complex, prolonging its half-life to approximately 16 hours (71)

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We express our gratitude to Pengfei Gong, Ruipei Ouyang, and Yongjie Shi from Jiangsu Province Engineering Research Center of Synthetic Peptide Drug Discovery and Evaluation, China Pharmaceutical University , for helping revise the manuscript