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The inhaled tobacco smoke is composed of two phases: the particulate (tar) phase containing stable free radicals, and the gas phase, which contains toxins and free radicals

NADPH levels are maintained by G6PD, meaning in G6PD-deficient RBCs, GSH is not restored to adequate levels under oxidative stress, leading to a buildup of free radicals and insoluble hemoglobin within the cell

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