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Patients who skip doses frequently or stop treatment early often experience: Reduced effectiveness Increased side effects when restarting Weight regain Difficulty maintaining appetite control I also remind patients that GLP-1 medication works best when combined with: Higher protein intake Portion control Resistance training or exercise Sleep optimisation Reduced liquid calories and snacking Without lifestyle adjustments, long-term success becomes much harder

A large real-world cohort study published in JAMA compared tirzepatide and semaglutide in adults with overweight or obesity

And while alternative medications to semaglutide may kick-start your journey, all of them (including drugs like Ozempic) may need to be taken long-term to keep the pounds off

No other symptoms If you do not feel dizzy, faint, or have chest pain along with your palpitations, they are less likely to be a serious problem