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These variables, which were selected because they are likely to affect treatment outcomes, encompassed both demographic factors (region, sex, age at index date) and clinical history (baseline HbA1c, baseline weight, CVD in the past 365 day [coronary heart disease, cerebrovascular disease, peripheral vascular disease or heart failure], CharlsonDeyo risk index score), as well as index year, insurance type and previous receipt of oral antidiabetic medications

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For example, Wegovy received FDA approval in 2024 to reduce the risk of serious cardiovascular events in adults who have cardiovascular disease in addition to obesity or overweight