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As for the more general TKIs the sequence homology between IGF-1R and IR-A/B kinase domains presented a major problem and therefore side effects were of great concern ( The IGF-signalling system has long been an area of therapeutic interest in the treatment of breast cancer which was further supported by the findings of both the European Prospective Investigation into Cancer and Nutrition (Kaaks et al., 2014) and the Endogenous Hormones and Breast Cancer Collaborative group (Murphy et al., 2020)

Curr Top Med Chem (2022) 22:17315

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Protects from UV Damage: Shields your skin from harmful UV rays, preventing discoloration and photo-aging, while keeping your skin hydrated and fresh