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VHL changes in RCC lead to the activation of HIF and its downstream target VEGF, and to the reprogramming of multiple cell death pathways and metabolic weakness, including ferroptosis, which are associated with targeted therapy

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The mice were housed in a specific-pathogen-free (SPF) facility at Zhejiang University, where they were maintained under controlled conditions of temperature (22 2 C) and humidity (50 10%), with a constant 12-h light/dark cycle