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These sensors are primarily composed of a class of proteins known as PRRs, which detect pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), thereby activating downstream inflammatory signaling pathways, promoting the release of pro-inflammatory cytokines, and inducing the activation of effector cells [86]

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Researchers who need to replicate the foundational incretin literature, establish single-receptor baselines for comparative studies, or specifically study GLP-1R mechanisms without the additional variables introduced by dual or triple agonism will find GLP-1(Sema) is still the correct compound for those protocols