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The mechanism of ferroptosis and applications in tumor treatment

The selenoprotein family of iodothyronine deiodinases consists of three enzymes, D1, D2 and D3, which are specifically distributed in tissues and regulate the activation and inactivation of TH: type 1 and 2 deiodinases (D1/D2) catalyse the conversion of the inactive precursor thyroxine (T4) to the active form, triiodothyronine (T3), while type 3 deiodinases (D3) terminate the hormones action by degradation ( 5 Hcy and thyroid diseases 5.1 Hcy and thyroid nodules In recent decades, with the widespread availability of ultrasound technology, thyroid nodules have become a common clinical disease