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In a previous study that matched populations from the Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes (SUSTAIN 6) and Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND) cardiovascular outcome trials using the propensity score method, semaglutide reduced 3-point MACE (cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke) by 26% compared to dulaglutide, although the reduction was not statistically significant (hazard ratio [HR], 0.74

The weight loss efficacy of prescription semaglutide (15% average body weight loss) and tirzepatide (20% average body weight loss) in clinical trials is not achievable through any currently available supplement