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Later, in October, a research letter published in JAMA indicated serious gastrointestinal problems in some obese patients treated with GLP-1 agonists

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Some researchers who experience GLP-1 injection site reactions find that warming the solution to room temperature beforehand reduces irritation significantly

Others switch to a higher concentration like 5mg/mL once they reach maintenance dosing to keep unit measurements more manageable, though this requires ordering a new vial mixed at the different strength