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Serious symptoms are uncommon but need medical attention, including significant swelling, chest pain, shortness of breath, sudden vision changes, allergic reaction symptoms, or major mood changes
(3) 1000 mg metformin at t = 0 min and 0.9% saline at t = 60 and 30 min [Met (0 min)]
This stepwise approach minimises gastrointestinal side effects such as nausea and vomiting
Demonstrated clinical benefits of GLP-1s include improved cardiometabolic risks, fewer major adverse cardiovascular events [22], decreased mortality in heart failure [[23], [24], [25], [26], [27]], and improvements in obstructive sleep apnea [11,28], prediabetes [29,30], chronic kidney disease [31], knee osteoarthritis [32], substance use disorders [33], and metabolic-associated steatotic liver disease [34]
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