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Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

Preclinical combination studies confirm that simultaneous GLP-1R and GIPR activation outperforms either receptor alone for weight reduction and glycemic control

Furthermore, it was demonstrated that GLP-1 receptor plays a regulatory role in the hippocampal function and GLP-1 receptor agonists enhanced GABAA signaling through pre-and postsynaptic mechanisms in rats [57], while exendin-4 therapy normalized cognitive dysfunction and improved impaired hippocampal synaptic plasticity in a mice model of diet-induced obesity [58]