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Ex-4 also restores SERCA2a expression and activity via the eNOS/cGMP/PKG pathway, reducing cytoplasmic Ca 2+ levels and suppressing structural remodeling in HF rats [64]

Eur J Pharmacol 323:173180 Bai F, Lau SS, Monks TJ (1999) Glutathione and N -acetylcysteine conjugates of -methyldopamine produce serotonergic neurotoxicity: possible role in methylenedioxyamphetamine-mediated neurotoxicity

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A change in TZD regimen from rosiglitazone to pioglitazone at specified, equivalent therapeutic doses was permitted at the investigators discretion if believed to be medically appropriate