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The pills havent been compared head-to-head in a clinical trial, but in separate studies, the Wegovy pill showed average weight loss of 14% over 64 weeks, compared with 2% for a placebo, while orforglipron showed 11% weight loss over 72 weeks on its highest dose, compared with 2% for the placebo group

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What does this mean for patients & our practice GLP-1 treatment with semaglutide can offer cardiovascular protection beyond pure weight loss, a potentially valuable tool in treating overweight, together with established cardiovascular disease

For example, Zepbound can cost $45 to $65 per month with certain Kaiser Permanente Federal Employee Health Benefits (FEHB) plans