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Vitamin B12 deficiency Having trouble absorbing vitamin B12 from food, lacking intrinsic factors (for example, as a result of pernicious anaemia), having gastrointestinal surgery, taking certain medications for an extended period of time (such as metformin or proton pump inhibitors), and nutritional deficiencies are all causes of vitamin B12 deficiency

Much of the discussion surrounding it is based on laboratory and animal research rather than large, peer-reviewed human trials

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Research endpoints include VEGF-associated signaling, neovascularization, granulation-tissue development, and collagen deposition