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Semaglutide and tirzepatide work by activating GLP-1 receptors in the pancreas to stimulate the production of insulin, which helps to control blood sugar levels in people with type 2 diabetes
The primary molecular actions relevant to skin are: modulation of TGF- signaling (upregulating TGF-1 for collagen I/III synthesis while suppressing TGF-2 to prevent scarring), decorin upregulation for orderly collagen fibril assembly, MMP suppression paired with TIMP upregulation to preserve ECM integrity, and copper-dependent lysyl oxidase activation for collagen crosslinking
That means: No voice deepening No facial or body hair growth No disruptions to the menstrual cycle No clitoral enlargement or other masculinizing effects This makes IGF-1 LR3 a strong option for women aiming to improve recovery, lean mass, and body composition without sacrificing femininity
Plant Cell and Environment
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