hospitalization required Maintenance of Remission: Immunomodulators (azathioprine, 6-MP, methotrexate) for steroid-dependent or frequently-relapsing disease Biologic monotherapy or combination therapy (biologic + immunomodulator) for moderate-to-severe disease Step-up or top-down approach based on disease severity, patient risk factors, and prior therapy Biologic Therapy Targets: TNF-: Infliximab (IV), adalimumab (SC), certolizumab pegol (SC) IL-12/23: Ustekinumab (IV induction, SC maintenance) Integrin: Vedolizumab (IV) IL-23: Risankizumab (IV induction, SC maintenance) JAK inhibition: Upadacitinib (oral) Surgical Management Surgery is indicated in approximately 7080% of patients with Crohns disease over their lifetime, per StatPearls
The CK-induced decrease in the integrity of the BBB model was attenuated significantly by 3-PLG-ibu-A-GSH in all three types of experiments (Figs
Focus areas: Establish hydration habits now, before higher doses make GI symptoms more pronounced Track protein intake for at least one week to establish a baseline Begin or maintain light exercise (walking 20 to 30 minutes daily) Get bloodwork done if you do not have recent results (ferritin, B12, vitamin D, metabolic panel) Start an electrolyte supplement if experiencing any nausea or GI symptoms The goal at this stage is building habits that will protect you at higher doses
Very easy to inject yourself and much more cost effective than going into the office
