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However, the mechanism of such intestinal toxicity is not entirely understood, mechanistic studies demonstrated oxidative stress and inflammatory reactions as key factors that lead to the development of MTX-induced intestinal injury

Perakakis N, Stefanakis K, Feigh M, Veidal SS, Mantzoros CS

Once absorbed, cells start making more energy

In light of the growing global burden of non-communicable diseases and the limitations of long-term pharmacotherapy, the review highlights how bioactive compounds derived from natural sources such as polyphenols, flavonoids, probiotics, and plant-based alkaloids may offer effective adjuncts or alternatives to conventional treatments