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Whole-cell radioligand-binding assay Cells were seeded at a density of 30,000 cells/well into 96-well culture plates and incubated overnight in DMEM containing 5% FBS at 37 C in 5% CO 2

Measurements were taken after adding 0.1 M Oligomycin (MZ8002-1MG, Mochaon Biotech, Zhejiang, China), 0.05 M FCCP (MX3259-100UL, Mochaon Biotech, Zhejiang, China), 1 M Rotenone (MX7451-1G, Mochaon Biotech, Zhejiang, China), and 10 M Atpenin A5 (HY-126653, MedChemExpress, USA)

Most (86%) were women

Treatment with semaglutide tablets 14 mg once daily for 26 weeks resulted in a statistically significant reduction in HbA 1c from baseline compared to placebo (see Table 8 )