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For example, approximately 6.3% of people with diabetes worldwide suffer from diabetic foot ulcers (DFUs), and an estimated 8 million people live with chronic wounds that often progress to severe complications such as sepsis or amputation [1]

By blocking NNMT, 5-Amino-1MQ prevents nicotinamide methylation, allowing NAD+ levels to rise and methyl groups to remain available for histone methylation and other epigenetic processes