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Its small size confers favorable physicochemical properties for solubility, stability, and intranasal or subcutaneous delivery, but also raises questions about specificity that are common to short peptides in vivo proteolytic stability, off-target binding, and minimum receptor recognition motif identification all require additional characterization that the published literature does not yet fully provide

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doi: 10.1073/pnas.0735876100 187 El-GayarSThring-NahlerHPfeilschifterJRllinghoffMBogdanC