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Potential Benefits Under Clinical Study While research is ongoing, clinical trials for Retatrutide have highlighted several areas of potential improvement in cardiometabolic health : Meaningful Weight Reduction: Studies have explored significant percentages of body weight loss over extended periods

A lot of the time, what feels like a plateau is actually part of the normal pattern of weight loss, not a sign that the medication has stopped working

[1] [4] Phase 2 trials are designed to assess safety and preliminary efficacy in relatively controlled conditions

Avoid Desvenlafaxine (Pristiq), Duloxetine (Cymbalta), and Venlafaxine (Effexor) which fall into this SNRI category as they increase norepinephrine in the synapse and can increase sympathetic drive, already a problem for many POTS patients