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Heart palpitations on semaglutide are usually indirect consequences of the body adjusting to a powerful metabolic medication, driven primarily by dehydration, electrolyte shifts, and the physiological demands of dose escalation

21 Pharmacists should also counsel patients on the importance of maintaining adequate hydration, especially in the presence of vomiting or diarrhea, to prevent dehydration and reduce the risk of acute kidney injury

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Patients with pre-existing conditions such as cardiovascular disease, kidney impairment, or diabetes should have a lower threshold for seeking advice