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For example, ABBV-969 is a novel PSMAxSTEAP1-directed bispecific ADC carrying a TOPI inhibitor payload with broader activity than ADCs targeting only PSMA or STEAP1 in preclinical mCRPC models, and is undergoing a phase I trial in mCRPC patients (NCT06318273) 120

Safety and outcomes in this population are unknown

No dose adjustment is required for either medication when used in combination

8 weeks: ~4 vials 12 weeks: ~6 vials 16 weeks: ~8 vials Insulin Syringes (U-100, 1 mL) Per injection: 1 syringe 8 weeks (once daily): ~56 syringes 16 weeks (once daily): ~112 syringes Bacteriostatic Water (10 mL bottles) Use ~3.0 mL per 10 mg blend vial for reconstitution