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10.7554/eLife.07242 37 LiuD.HuY.WangD.HanH.WangY.WangX.et al (2023)

2 Storage vs Utilization Metabolic state determines lipid fate: Fed state (Insulin dominant): Lipoprotein lipase activity Triglyceride storage in adipose tissue Fasting state (Glucagon/Epinephrine dominant): Activation of hormone-sensitive lipase Lipolysis Free fatty acids -oxidation Hepatic ketogenesis when glucose is limited Lipids are not inherently pathological

As life expectancy decreases, the benefits derived from lowering blood glucose levels are considered to diminish [5]