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Bismuth subsalicylate is chemically related to aspirin (acetylsalicylic acid), and this relationship has important implications for its use

This bi-genomic signaling mechanismcommunicating between two separate genetic systemsmakes it particularly valuable for studying how cellular stress responses coordinate metabolism, aging, and physical performance across multiple organ systems

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10.1007/s10565-025-10101-y Summary Keywords GRP78, HSC70, HSPA1A, molecular chaperones, mortalin, protein quality control Citation Pustovaya K, Venediktov A, Soldatov V, Kuzmin E, Pokidova K, Gartzeva V, Payushina O, Tsytsarev V, Meglinski I and Piavchenko G (2026) Recent insights into HSP70: proteostasis and beyond