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Orforglipron treatment led to a significant reduction in body weight compared with controls

More help Essentiality of the Key Events The essentiality of KEs can only be assessed relative to the impact of manipulation of a given KE (e.g., experimentally blocking or exacerbating the event) on the downstream sequence of KEs defined for the AOP

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In addition, sodium/hydrogen exchanger 1 (NHE-1), a membrane-bound enzyme, is thought to be partly mediated by AngII and involved in modulating intracellular acidity