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IGF2BP3 knockdown, degradation, and serine/glycine deprivation exert synergistic inhibitory effects on AML in vitro and in vivo ( Studies have also found that AML cells, particularly the subtype harboring FLT3-ITD mutations, exhibit high serine dependence

While these observational studies cannot prove causation, the consistency of the signal across different populations, healthcare systems, and analytical methods has strengthened the case for randomized trials

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