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XYC, QZ, JG participated in the study design and manuscript revising

Although a plethora of tumor cell mechanosensors have been identified, including focal adhesions, ion channels, actin cytoskeleton, nuclear proteins, and transcription factors, more research is needed to uncover how breast cancer cells convert biophysical signals into biochemical cues to mediate short- and long-term mechanoresponses ( Table 5 )

The personalized dosing approach gets frequent praise from patients who previously had negative experiences with standard GLP-1 titration on other platforms