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For instance, mutations in genes such as NRXN1, CACNA1C, and CNTNAP2 have produced diverse phenotypic outcomes depending on the genetic variant and individual susceptibility

Circ Res 87 : 4551

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The hypothesis that smoking and the level of glutathione peroxidase 1 activity had an interactive effect on the risk of future cardiovascular events was formally tested in a Cox regression model that included a term for the multiplicative interaction of smoking (across the three categories of smoking status) and glutathione peroxidase 1 activity