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Mol Cell Biochem 278:101109 Geetha S, Jayamurthy P, Pal K et al (2008) Hepatoprotective activity of Sea buckthorn ( Hippophae rhamnoides L.) against carbon tetrachloride induced hepatic damage in rats

Drugs of abuse increase BBB permeability, which, in turn, increases influx of peripheral toxins into the brain

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Insufficient drug delivery into the brain leads to low therapeutic efficacy as well as aggravated side effects due to the accumulation in other organs and tissues