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It works by inhibiting the DPP-4 enzyme, which normally breaks down incretin hormones such as GLP-1 (Glucagon-Like Peptide-1) and GIP (Gastric Inhibitory Polypeptide) which help to increased insulin secretion to stimulate the pancreas to release more insulin in response to meals, particularly when blood sugar levels are elevated and decreased glucagon secretion is a hormone that signals the liver to produce glucose

A recent study (63) demonstrated that ferroptosis propagates in a ROS-triggered wave-like manner, enabling large-scale cell death within cell populations

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