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The mechanism is not fully understood, but theories include: Changes in blood flow to the optic nerve Rapid weight loss affecting ocular circulation Metabolic changes affecting eye health Legal Development: Vision loss cases are being consolidated into a separate MDL (MDL 3163) also overseen by Judge Marston

Since DA-resistance of prolactinomas has been associated with increased invasiveness and aggressiveness of these tumors ( Up to now, no data are present in literature about the effects of FLNA expression levels on pituitary cell migration and invasion, and further studies are required to test a possible contribution of FLNA alterations in the invasiveness, aggressive behavior, and recurrences of pituitary tumors

In this part of the trial, as expected, brodalumab showed the most benefit in the ACR20 of those previously on placebo