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This, in turn, facilitates the augmented transport of glutamine into the mitochondria of cancer cells, ultimately leading to heightened ATP production induced by glutamine and the synthesis of glutathione [50]

Mitochondria-targeted antioxidant MitoQ, a mitochondria-specific coenzyme Q10 analog, alleviates podocyte apoptosis and tubular epithelial necrosis in diabetic kidney disease by scavenging mitochondrial ROS and restoring mitophagy via the Nrf2/PINK1 signaling pathway

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However, with IBD-current biologic therapies, all these mean some patients primary non-responders, experience a loss of response, intolerance or side effects, defining the urgent unmet need for novel treatments (13, 14)