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Corroborating animal models further demonstrate that combining pyridostigmine, stress, and other Gulf War toxicants (such as DEET and permethrin) causes neuroinflammation as well as cognitive, spatial navigation, memory and sensorimotor deficits that mirror Gulf War Illness (White et al, 2016)

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Furthermore, the well documented efficacy of combined folic acid, B6, and B12-vitamin supplementation to reduce hyperhomocysteinemia could enhance GSH activity and reduce oxidative stress (161)