b , i , l , o , Venn-diagram with differentially regulated proteins (DRPs) over vehicle in pancreas ( b ), eWAT ( i ), liver ( l ) and skeletal muscle ( o )
For instance, past studies show that GLP-1s may also aid in treating cardiovascular disease, chronic kidney disease, non-alcoholic fatty liver disease (NAFLD), polycystic ovary syndrome (PCOS), and rheumatic diseases, such as rheumatoid arthritis and osteoarthritis
Gastrointestinal side effects may induce fatigue Gastrointestinal issues like nausea and diarrhea are more common Wegovy side effects than fatigue
As alluded to above, the rationale for combining GLP-1R agonism with either GIPR agonism or antagonism is, however, still debated, and how the GIPR agonistic properties of tirzepatide contribute to body-weight loss remains unclear [19]