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Just as importantly, they can help patients determine whether medication, lifestyle intervention, or a combination of both is the best fit for their goals and preferences

108 Overall, these studies suggest that although weight loss from dietary restriction can compromise skeletal health, incorporating exerciseparticularly endurance trainingcan preserve BMD and hormonal factors, and reduce bone resorption, thereby offering partial protection to the skeleton during obesity treatment

A.TriantafyllouG.DincerF.FilippaiosA.KoB.-J.et al

If taking insulin or sulfonylureas for diabetes, the dose of those medications may need to be lowered when starting Zepbound to reduce the risk of hypoglycemia (low blood sugar)