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FDA-approved GLP-1 drugs like Wegovy are explicitly cleared for weight loss in people with a BMI over 30 and for those with a BMI below 27 who have weight-related comorbidities like diabetes, hypertension, high cholesterol, and sleep apnea

Hypertension 69 , 10361044 (2017)

Read more Explore which GLP-1 medicationZepbound, Wegovy, or Ozempicis most effective for you in 2025

Furthermore, impaired communication between the ER and mitochondria-especially through mitochondria-associated membranes (MAMs)-appears to exacerbate these stress responses, reinforcing the interplay between calcium dysregulation, redox imbalance, and cell death