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The main incretin hormones secreted by the epithelial cells of the gastrointestinal track are glucagon-like peptide-1 (GLP)-1 and glucose-dependent insulinotropic peptide, also known as Gastric Inhibitory Polypeptide (GIP), which stimulate the pancreatic cells ( and cells) and regulate insulin secretion with respect to blood glucose concentration ( The first incretin to be reported was GIP

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