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Real-world retrospective analysis of data from the Barbara Davis Center compared type 1 diabetes patients on semaglutide and tirzepatide off-label over one year: 9.1% vs 21.4% body weight reduction and HbA1c reductions of 0.54% vs 0.68%, respectively [12]

Adipose tissue plays a role in oestrogen metabolism, and changes in body composition might temporarily influence the hypothalamic-pituitary-ovarian axis, though this remains speculative

Aten Primaria (2017) 49:2949

This means more people can stay on tirzepatide at effective doses compared to semaglutide, which is a meaningful advantage when the goal is long-term use