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ER expression was significantly decreased in the uteri of OVX rats, whereas no obvious decrease in ER expression was observed

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SUPEROXIDE, HYDROGEN PEROXIDE, AND PEROXYNITRITE GENERATION Despite the fact that superoxide can be generated in extramitochondrial reactions, in most cell types mitochondria appear as the main source of superoxide generation

However, GSH has an overall negative charge at physiological pH, and mitochondria also exhibit an enormous negative membrane potential [57, 58]