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This patient population was hospitalized with advanced alcoholic cirrhosis and had evidence of anorexia and malnutrition (Rudman et al., 1977)

While overall exposure (AUC) was broadly comparable across sites, peak concentrations (Cmax) were modestly lower with thigh and upperarm injections compared with abdomen

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We find that the binding site of both compounds is identical to that for a similar molecule that remains naturally attached to the virus 7 , and to the binding site observed for the benzene-sulfonamide derivative in complex with Coxsackievirus B3 8 , identifying the biological role for this binding site