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Necroptosis, triggered when apoptosis is impaired, involves receptor-interacting protein kinases (RIPK) 1 and 3, and the mixed lineage kinase domain-like protein (MLKL), resulting in membrane rupture and inflammatory signaling [149]

In Europe, recent shortages of Type IV patch test allergens further contribute to lack of testing availability in some settings, potentially prolonging time to diagnosis and symptom control for those with suspected ACD [42, 43, 45,46,47]

Using EdU labeling with a 24-h chase, we observed sustained EdU signal beyond S-phase, indicating enhanced progression through the cell cycle in mog-3(-) mutants (Supplementary Fig