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GLP-1 increases insulin secretion in response to nutrients and suppresses glucagon secretion from pancreatic islet cells, reducing postprandial glucose levels ( Some studies suggest that GLP-1 RAs may benefit kidney outcomes, especially in improving albuminuria ( Others Endothelin receptor antagonists (ERAs) such as atrasentan and eprosartan have been associated with renal protection when combined with RAAS blockade ( Conclusions Nephroprotection is a cornerstone in preserving renal damage in patients with lupus nephritis ( Figure 1 )

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