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Hedrich CM, Tsokos GC (2011) Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases

IGF-1 is released from IGFBPs by mechanisms involving extracellular matrix (ECM) binding or proteolysis in the linker domain (Schedlich et al., 2000), and 6 (Iosef et al., 2008) contain a nuclear localisation sequence

The perceived sleep improvement may partly reflect this timing strategy rather than a true sedative effect