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However, it is not known whether vitamin B 12 supplementation, in addition to folic acid supplementation, may be beneficial in the prevention of NTD (62) randomized controlled trials are needed to address this question

This interaction reduces inhibitory binding between caveolin-1 and endothelial nitric oxide synthase, allowing increased enzyme activity and nitric oxide production in endothelial cells

17:227-232 [PubMed: 16680026] 41