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The net result of the activation of AMPK will restore the energy balance, inhibiting the anabolic pathways responsible for the synthesis of macromolecules, such as proteins and glycogen, and also of the following lipids: fatty acids, triglycerides and cholesterol, while activating the catabolic pathways, such as the oxidation of fatty acids, glucose uptake and glycolysis [101] (Figure 3)

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About half of the participants received weekly injections of semaglutide, with the rest receiving placebo injections