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10.1016/j.pnpbp.2010.11.011 30

A single-center, double-blinded, randomized controlled study to evaluate the relative efficacy of sublingual and oral vitamin B-complex administration in reducing total serum homocysteine levels

Benefits: Improves circadian rhythm by promoting the delta rhythm, achieved in Stage 4 of sleep (the stage when Growth Hormone is made) Antioxidant effect in the brain via increases in glutathione peroxidase and superoxide dismutase Increased alertness, improved stress tolerance, and coping behavior during awake cycles Restoration of slow-wave sleep in Cushings Syndrome Possible anticonvulsant action by increasing the threshold to NMDA- and picrotoxin-induced convulsions Increase in testosterone levels when treating with DSIP alone (100-200 point increases have been observed) Side Effects: Potential to disrupt sleep

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