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Simultaneously, Deacon et al (72) demonstrated cleavage of GLP-1 [736] amide to GLP-1 [936] amide in human plasma in vitro, with these actions sensitive to the DPP4 inhibitor diprotin A, findings consistent with those reported by Pauly et al (140) analyzing the degradation of GIP and GLP-1 by human serum in vitro

"Most of these changes are caused by the weight loss itself, along with secondary effects such as metabolic and nutritional changes that can occur with rapid weight loss," Son says

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